| Place of Origin: | CHINA |
|---|---|
| Brand Name: | HEMMAN |
| Certification: | ISO9001 2015 |
| Model Number: | HM-21 |
| Minimum Order Quantity: | 1kg |
| Price: | Negotiable |
| Packaging Details: | according to your requirments |
| Delivery Time: | 5-8 days |
| Payment Terms: | L/C, D/A, D/P, T/T |
| Supply Ability: | 1000 kgs per day |
| IUPAC NAME: | Pyridine-3-carboxamide | CAS NO: | 98-92-0 |
|---|---|---|---|
| Chemical Formula: | C₆H6N2O | Molar Mass: | 122.12g·mol⁻¹ |
| Properties: | White Crystalline Powder | Another Name: | Vitamin B3 |
| High Light: | microcrystalline cellulose powder,ethyl cellulose powder |
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Prevention And Treatment Of Pellagra Medicine Raw Material With Stomatitis And Glossitis
Nicotinamide is a water-soluble vitamin and a member of the B vitamin family. Nicotinic acid can be converted into nicotinamide in vivo. Although both compounds have vitamin effects, nicotinamide is less toxic and pharmacological than nicotinamide. These effects are produced during the transformation of nicotinamide. Therefore, nicotinamide does not reduce cholesterol or cause flushing as nicotinic acid does. When adults take in more than 3 g a day, it can cause liver toxicity. In cells, nicotinic acid is used to synthesize nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphoric acid (NADP). For nicotinamide, the pathway of transformation is very similar to that of nicotinamide. NAD + and NADP + are coenzymes for various enzymatic redox reactions.
IUPAC name: pyridine-3-carboxamide
Alias: 3-pyridine carboxamide, niacinamide, nicotinamide, nicotinicacidamide, VitaminPP
Chinese aliases: nicotinamide, vitamin B3, vitamin PP, nicotinamide; B3, VPP, 3-pyridylformamide
CAS No. 98-92-0
PubChem: 936
ChemSpider: 911
SMILES: c1cc (cnc1) C (= O)N
InChI:1/C6H6N2O/c7-6(9) 5-2-1-3-8-4-5/h1-4H, (H2, 7, 9)/f/h7H2
ChEBI: 17154
DrugBank: DB02701
KEGG:D00036
Chemical formula: CH6N2O
Molar mass: 122.12 g. mol_
Melting point: 128-131 degree C
Uses: Vitamin drugs, participate in the body's metabolic process, for the prevention and treatment of pellagra and other nicotinic acid deficiency
(All data are from 25 C, 100 kPa)
Fold and edit the medicine in this paragraph
Folding Basic Information
English/Latin Name: Nicotinamide
Dose/usage: oral, 50-200 mg once, 150-600 mg a day
Alias: nicotinamide, nicotinamide, nicotinamide, vitamin B3, vitamin PP.
Preparations/specifications: 1. Tablets: 50mg, 100mg. (2) Injection: 50mg/ml or 100mg/ml.
Category: Vitamins
Folding traits
The product is white crystalline powder; odorless or almost odorless, bitter taste. The product is soluble in water or ethanol and dissolved in glycerol. Melting point The melting point of this product is 128-131 C.
Folding function and dominance
It is mainly used to prevent and treat pellagra with stomatitis and glossitis. (2) Sick sinus syndrome. (3) Atrioventricular block (no effect on complete right bundle branch, left bundle branch, left anterior branch, double bundle branch or three bundle branch block).
Clinical application of folding
It is used clinically for arrhythmias associated with coronary heart disease, viral myocarditis, rheumatic heart disease and a few digitalis poisoning (most of which are used only after other drugs are ineffective). Generally, all degrees of atrioventricular block have obvious curative effect, basically after treatment, conduction block can disappear, sick sinus syndrome has obvious curative effect, bundle branch block has poor curative effect.
Adverse folding reactions
Individual patients may have dizziness, nausea, epigastric discomfort, loss of appetite, etc.
Folding usage and dosage
nicotinamide
nicotinamide
(1) Prevention and treatment of pellagra, stomatitis and glossitis: oral administration, 50-200 mg once, 3 times a day. If oral absorption is poor, add glucose solution intravenously, 25 mg each time, twice a day. At the same time, other vitamin B and vitamin C were added.
(2) Prevention and treatment of cardiac block: 300-400 mg once, once a day, add 10% glucose solution 250ml intravenous drip, 30 days as a course of treatment.
Folding pharmacological action
This product is a water-soluble vitamin. This product is easy to absorb orally and can be widely distributed in the body. Excess part of the product is quickly excreted from urine by metabolites or prototype. This product is a component of coenzyme I and coenzyme II. It plays a role of hydrogen transfer in the respiratory chain of biological oxidation. It can promote the process of biological oxidation and tissue metabolism. It plays an important role in maintaining the integrity of normal tissues (especially skin, digestive tract and nervous system). In addition, it has the effects of preventing and treating cardiac block, improving sinoatrial node function and resisting rapid experimental arrhythmia. It can significantly improve the heart rate slowdown and atrioventricular block caused by verapamil.
Pay attention to folding
(1) Intramuscular injection can cause pain, so it is seldom used.
(2) Individual can cause dizziness, nausea, epigastric discomfort, loss of appetite and so on, which can disappear by itself.
(3) Overdose in the early pregnancy may cause teratogenesis.
(4) Both isoniazid and nicotinamide have antagonistic effects. Nicotinamide should be supplemented for long-term use of isoniazid in liver.
